Title : Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast invasion.

Pub. Date : 2009 Nov 25

PMID : 19939245






3 Functional Relationships(s)
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1 RESULTS: We found that Forskolin increased MMP-2 mRNA in JAR cells within 24 hours, and induced binding to p53, Ets, C/EBP and AP-2. Colforsin CCAAT enhancer binding protein alpha Homo sapiens
2 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin CCAAT enhancer binding protein alpha Homo sapiens
3 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin CCAAT enhancer binding protein alpha Homo sapiens