Title : Pharmacokinetics of mirodenafil and its two metabolites, SK3541 and SK3544, after intravenous and oral administration of mirodenafil to streptozotocin-induced diabetes mellitus rats.

Pub. Date : 2010 Feb

PMID : 19929308






1 Functional Relationships(s)
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1 This may be explained by the significantly faster hepatic CL(int) of mirodenafil, owing to increased hepatic CYP1A, CYP2B1/2, CYP2D, and CYP3A expression, and a faster hepatic blood flow rate, compared with control values. mirodenafil cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus