Title : Bradykinin and high glucose promote renal tubular inflammation.

Pub. Date : 2010 Mar

PMID : 19923143






2 Functional Relationships(s)
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1 Inhibition of MAPK p42/p44 by PD98059 partially reduced HG and BK induction of IL-6, CCL-2 and TGF-beta, whereas inhibition of PKC by staurosporine partially reduced HG- but not BK-induced overexpression of these cytokines and that of VEGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one C-C motif chemokine ligand 2 Homo sapiens
2 Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one C-C motif chemokine ligand 2 Homo sapiens