Title : Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase.

Pub. Date : 2010 Jan 29

PMID : 19917609






1 Functional Relationships(s)
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1 X-ray crystal structures of Rhodobacter capsulatus ALAS reveal that a conserved active site serine moves to within hydrogen bonding distance of the phenolic oxygen of the PLP cofactor in the closed substrate-bound enzyme conformation and within 3-4 A of the thioester sulfur atom of bound succinyl-CoA. succinyl-coenzyme A aminolevulinic acid synthase 1 Mus musculus