Pub. Date : 2010 Mar-Apr
PMID : 19914848
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined the effect of the anthracyclines aclarubicin, bleomycin, daunorubicin, doxorubicin and idarubicin on human gamma- and beta-globin promoter activity in an in vitro luciferase assay, ex vivo in erythroid cultures and in vivo in transgenic mice carrying the human gamma-globin gene. | Daunorubicin | hemoglobin subunit gamma 1 | Homo sapiens |
| 2 | Daunorubicin induced HbF in thalassaemic cells ex vivo with the highest statistical significance and, importantly and in contrast to the clinical HbF inducer hydroxyurea, showed specific induction of gamma-globin without associated induction of alpha-globin. | Daunorubicin | hemoglobin subunit gamma 1 | Homo sapiens |
| 3 | Daunorubicin was screened in transgenic mice carrying the human (A)gamma-globin gene, and it resulted in increased (A)gamma-globin mRNA levels. | Daunorubicin | hemoglobin subunit gamma 1 | Homo sapiens |
| 4 | Daunorubicin was screened in transgenic mice carrying the human (A)gamma-globin gene, and it resulted in increased (A)gamma-globin mRNA levels. | Daunorubicin | hemoglobin subunit gamma 1 | Homo sapiens |