Pub. Date : 2010 Feb 3
PMID : 19909793
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 2 | By using in situ hybridization and western blotting methods the aim of present study was to analyse the potential regulatory role of selective mGluR2/3 agonist LY379268 treatment on brain derived neurotrophic factor (BDNF) expression in the mouse brain. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 3 | By using in situ hybridization and western blotting methods the aim of present study was to analyse the potential regulatory role of selective mGluR2/3 agonist LY379268 treatment on brain derived neurotrophic factor (BDNF) expression in the mouse brain. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 4 | The treatment with LY379268 evidenced a significant upregulation of BDNF mRNA levels in the cerebral cortex and in the hippocampal formation with a peak at 3 h from treatment and its disappearance already at 6 h from treatment. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 5 | An analysis of dose-effect curve revealed that LY379268 may significantly enhance BDNF mRNA expression already at dose of 0.250 mg/kg b.w. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 6 | The upregulation of BDNF mRNA expression was followed by a significant increase of BDNF protein levels at 24 h from LY379268 treatment. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 7 | The upregulation of BDNF mRNA expression was followed by a significant increase of BDNF protein levels at 24 h from LY379268 treatment. | LY 379268 | brain derived neurotrophic factor | Mus musculus |
| 8 | These effects of LY379268 treatment on BDNF expression were restricted to neuronal cells and were blocked by the new selective mGlu2/3 receptor antagonist LY341495, suggesting a receptor specificity. | LY 379268 | brain derived neurotrophic factor | Mus musculus |