Title : Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.

Pub. Date : 2010 Feb

PMID : 19906888






1 Functional Relationships(s)
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1 Treatment with metformin (10 mM) for 24 h reduced cell proliferation and the levels of cyclin D2 and E, and increased the associations cyclin D2/p21 and cyclin D2/p27 without affecting cell viability in response to IGF1 (10(-8) M). Metformin cyclin dependent kinase inhibitor 1A Bos taurus