Title : Analgesic activity of 3-mono-substituted derivatives of dihydrofuran-2-one in experimental rodent models of pain.

Pub. Date : 2009 Sep-Oct

PMID : 19904003






1 Functional Relationships(s)
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Protein Name
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1 For the most active derivative of dihydrofuran-2-one, L-PP1 (3-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride), the ED(50) value was: 1.34 mg/kg, 0.79 mg/kg, 2.01 mg/kg and 3.99 mg/kg in the hot plate, writhing, capsaicin- and glutamate-induced pain tests, respectively. 4-Butyrolactone phospholipid phosphatase 1 Mus musculus