Pub. Date : 2010 Mar
PMID : 19898896
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that the double mutant prestin(NN163/166AA) is not glycosylated and shows the expected NLC properties in the untreated and cholesterol-depleted HEK 293 cell model. | Cholesterol | solute carrier family 26 member 5 | Homo sapiens |
| 2 | In an attempt to explain this finding, we discovered that both WT prestin and prestin(NN163/166AA) participate in cholesterol-dependent cellular trafficking. | Cholesterol | solute carrier family 26 member 5 | Homo sapiens |
| 3 | In an attempt to explain this finding, we discovered that both WT prestin and prestin(NN163/166AA) participate in cholesterol-dependent cellular trafficking. | Cholesterol | solute carrier family 26 member 5 | Homo sapiens |
| 4 | In contrast to WT prestin, prestin(NN163/166AA) shows a significant cholesterol-dependent decrease in cell-surface expression, which may explain the loss of NLC function. | Cholesterol | solute carrier family 26 member 5 | Homo sapiens |
| 5 | We speculate that the cholesterol regulation of prestin occurs through localization to and internalization from membrane microdomains by clathrin- and caveolin-dependent mechanisms. | Cholesterol | solute carrier family 26 member 5 | Homo sapiens |