Title : The energy landscape of 3-deoxy-D-manno-octulosonate 8-phosphate synthase.

Pub. Date : 2009 Dec 15

PMID : 19891460






2 Functional Relationships(s)
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1 Earlier studies have established that the condensation occurs with a syn addition of water to the si side of C2(PEP) and of C3(PEP) to the re side of C1(A5P). Silicon heterogeneous nuclear ribonucleoprotein C Homo sapiens
2 In this study we calculated the potential energy surfaces (PESs) associated with all possible reaction paths in the active site of KDO8PS: the path involving a syn addition of water to the si side of C2(PEP) and of C3(PEP) to the re side of C1(A5P), with the PEP phosphate group deprotonated, has the lowest energy barrier ( approximately 14 kcal/mol) and is strongly exoergonic (reaction energy of -38 kcal/mol). Silicon heterogeneous nuclear ribonucleoprotein C Homo sapiens