Pub. Date : 2010 Feb
PMID : 19882354
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues. | Cyclic AMP | tumor protein p53 | Homo sapiens |
| 2 | Less well appreciated was the effect of cAMP levels on posttranslational modifications of p53 in response to doxorubicin. | Cyclic AMP | tumor protein p53 | Homo sapiens |
| 3 | Here we show that elevation of cAMP in pre-B acute lymphoblastic leukemia NALM-6 cells significantly attenuated phosphorylation state of p53 at Ser6, Ser9, Ser15, Ser20, Ser37, Ser46 and Ser392 upon exposure to doxorubicin. | Cyclic AMP | tumor protein p53 | Homo sapiens |
| 4 | In conclusion, our results suggest that activation of cAMP-signaling system may repress p53-dependent apoptosis in malignant cells exposed to doxorubicin. | Cyclic AMP | tumor protein p53 | Homo sapiens |