Title : Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis.

Pub. Date : 2010 May

PMID : 19876066

1 Functional Relationships(s)
Compound Name
Protein Name
1 Suppression of intracellular ROS induction using various pharmacological inhibitors or PKCdelta- or NOX4-specific RNA interference enhanced the enzymatic activity of caspase-3 by blocking the oxidative modification of its catalytic cysteine residue, resulting in marked augmentation of TRAIL-mediated cell death. Cysteine caspase 3 Homo sapiens