Title : Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.

Pub. Date : 2009 Dec 25

PMID : 19875446






9 Functional Relationships(s)
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1 Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
2 N-Arachidonylglycine (NAGly) is an endogenous inhibitor of GLYT2 with little or no effect on GLYT1 and is analgesic in rat models of neuropathic and inflammatory pain. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
3 N-Arachidonylglycine (NAGly) is an endogenous inhibitor of GLYT2 with little or no effect on GLYT1 and is analgesic in rat models of neuropathic and inflammatory pain. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
4 Understanding the molecular basis of NAGly interactions with GLYT2 may allow for the development of novel therapeutics. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
5 In this study, chimeric transporters were used to determine the structural basis for differences in NAGly sensitivity between GLYT1 and GLYT2 and also the actions of a series of related N-arachidonyl amino acids. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
6 Extracellular loops 2 and 4 of GLYT2 are important in the selective inhibition of GLYT2 by NAGly and by the related compounds N-arachidonyl-gamma-aminobutyric acid and N-arachidonyl-d-alanine, whereas only the extracellular loop 4 of GLYT2 is required for N-arachidonyl-l-alanine inhibition of transport. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
7 Extracellular loops 2 and 4 of GLYT2 are important in the selective inhibition of GLYT2 by NAGly and by the related compounds N-arachidonyl-gamma-aminobutyric acid and N-arachidonyl-d-alanine, whereas only the extracellular loop 4 of GLYT2 is required for N-arachidonyl-l-alanine inhibition of transport. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
8 Extracellular loops 2 and 4 of GLYT2 are important in the selective inhibition of GLYT2 by NAGly and by the related compounds N-arachidonyl-gamma-aminobutyric acid and N-arachidonyl-d-alanine, whereas only the extracellular loop 4 of GLYT2 is required for N-arachidonyl-l-alanine inhibition of transport. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus
9 Site-directed mutagenesis of GLYT2 EL4 residues was used to identify the key residues Arg(531), Lys(532), and Ile(545) that contribute to the differences in NAGly sensitivity. N-arachidonylglycine solute carrier family 6 member 5 Rattus norvegicus