Title : The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly.

Pub. Date : 2010 Jan

PMID : 19850678






2 Functional Relationships(s)
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1 The exon 3-deleted patients required approximately 20% lower doses of pegvisomant per kilogram of weight (28 +/- 11 compared to 22 +/- 7 mg per kg of weight; P = 0.033) to normalize IGF-I. pegvisomant insulin like growth factor 1 Homo sapiens
2 A stepwise multivariate linear regression analysis (R(2) = 0.40; P = 0.001) revealed that the only significant predictor of the time to IGF-I normalization was the dose of pegvisomant per kilogram of weight (beta = 0.451; P = 0.001). pegvisomant insulin like growth factor 1 Homo sapiens