Title : Insights into the reactivation of cobalamin-dependent methionine synthase.

Pub. Date : 2009 Nov 3

PMID : 19846791






1 Functional Relationships(s)
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1 The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state. Tyrosine mitochondrially encoded cytochrome c oxidase I Homo sapiens