Title : FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.

Pub. Date : 2009 Nov 1

PMID : 19843936






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mutational analysis showed the tyrosine residues in two potential ITIMs at 662 and 692 offer the main contributions to this inhibition, which is further supported by strong associations of SH-2 domain-containing phosphatases with the following phosphotyrosine motifs: SHIP with the ITIM-like motif at 662; and SHP-1 and -2 with the canonical ITIM at 692. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens