Title : Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302.

Pub. Date : 2010 Sep

PMID : 19838642






1 Functional Relationships(s)
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1 Many useful anticancer agents including bis-alkylating agents, cisplatin, and arsenic trioxide are known to interact with the selenocysteine dipeptide in the carboxy terminal region of thioredoxin reductase and inactivate its ability to reduce thioredoxin. Dipeptides peroxiredoxin 2 Mus musculus