Title : Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle.

Pub. Date : 2010 Jan

PMID : 19833896






3 Functional Relationships(s)
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1 OBJECTIVE: To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression. Fatty Acids, Nonesterified pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens
2 OBJECTIVE: To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression. Fatty Acids, Nonesterified pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens
3 The activation of PDH by exercise independent of changes in muscle glycogen or plasma FFA suggests that exercise overrules FFA-mediated inhibition of PDH (i.e., carbohydrate oxidation), and this may thus be one mechanism behind the health-promoting effects of exercise. Fatty Acids, Nonesterified pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens