Pub. Date : 2010 Jan
PMID : 19833203
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of three glutamine tracts in human androgen receptor transactivation. | Glutamine | androgen receptor | Homo sapiens |
| 2 | Here, we investigated whether 6 and 5 repetitive glutamine tracts (Q6 and Q5, respectively) in the N-terminal domain of AR also have effects on AR transactivation. | Glutamine | androgen receptor | Homo sapiens |
| 3 | In a reporter gene assay using two-tandem repeats of an androgen response element, deletion of glutamine tracts significantly increased AR transactivation in the following order: wild-type<a single deletion of polyQ or Q5<double deletion of polyQ and Q6<double deletion of polyQ and Q5<triple deletion. | Glutamine | androgen receptor | Homo sapiens |
| 4 | However, the glutamine tracts had no influence on activation function-1 activity, suggesting that the glutamine tracts modulate the binding of AR to DNA. | Glutamine | androgen receptor | Homo sapiens |