Title : Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells.

Pub. Date : 2009 Nov

PMID : 19796171






2 Functional Relationships(s)
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1 Here, we report that the tumor suppressor p53 is colocalized with FE65 in the nuclear patches and is stabilized by FE65 in sorbitol-treated cells. Sorbitol amyloid beta precursor protein binding family B member 1 Homo sapiens
2 In FE65 knockdown cells, protein levels of p53 targeted to the nuclear matrix were rapidly decreased through the proteasome degradation pathway after sorbitol treatment, as compared with control cells. Sorbitol amyloid beta precursor protein binding family B member 1 Homo sapiens