Title : Structure-activity relationship of taxol inferring from docking taxol analogues to microtubule binding site.

Pub. Date : 2009 Jul-Aug

PMID : 19791508






1 Functional Relationships(s)
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1 By comparing the interactions of each analogue with beta-tubulin, the structure-activity relationships are summarized as follow: C-2 benzoyl and taxane ring systems are the essential groups for microtubule binding, the improvements of bioactivity and bioavailability are dependent on the substituents at positions C-1, C-4, C-7, C-9, C-10, and C-14, whereas the C-13 side chain mainly provides a specific binding. taxane homeobox C10 Homo sapiens