Pub. Date : 2009 Nov
PMID : 19783898
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Stable transfection of dominant-negative AKT into resistant cells by retroviral infection restored their susceptibility to AZD6244. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These results indicate that phosphorylated AKT may be a biomarker of response to AZD6244 and that modulation of AKT activity may be a useful approach to overcome resistance to MEK inhibitors. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |