Title : EGCG induces apoptosis in human laryngeal epidermoid carcinoma Hep2 cells via mitochondria with the release of apoptosis-inducing factor and endonuclease G.

Pub. Date : 2010 Apr 1

PMID : 19781850






2 Functional Relationships(s)
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1 The levels of p53 were increased in the EGCG-treated cells, with a corresponding decrease in Bcl-2 and Bid protein levels as well as an increase in the Bax level. epigallocatechin gallate tumor protein p53 Homo sapiens
2 Taken together, these findings indicate that the p53-mediated mitochondrial pathway and the nuclear translocation of AIF and EndoG play a crucial role in EGCG-induced apoptosis of human laryngeal epidermoid carcinoma Hep2 cells, which proceeds through a caspase-independent pathway. epigallocatechin gallate tumor protein p53 Homo sapiens