Title : Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARgamma transcriptional activity.

Pub. Date : 2010 Sep

PMID : 19775880






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Daidzein also dose-dependently increased insulin-stimulated glucose uptake and the relative abundance of insulin-responsive glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS-1) mRNA. daidzein solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus
2 Furthermore, daidzein and equol up-regulated PPARgamma-mediated transcriptional activity, and daidzein restored the PPARgamma antagonist-induced inhibition of aP2 and GLUT4 mRNA levels. daidzein solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus
3 Our results indicate that daidzein enhances insulin-stimulated glucose uptake in adipocytes by increasing the expression of GLUT4 and IRS-1 via the activation of PPARgamma. daidzein solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus