Title : Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling.

Pub. Date : 2009 Oct 1

PMID : 19773444






3 Functional Relationships(s)
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1 Protein profiling identified MIC-1 and AGR2 as respectively up-regulated and down-regulated in Docetaxel-resistant cells. Docetaxel anterior gradient 2, protein disulphide isomerase family member Homo sapiens
2 Knockdown of AGR2 expression in PC3 cells resulted in Docetaxel resistance (P = 0.007). Docetaxel anterior gradient 2, protein disulphide isomerase family member Homo sapiens
3 These results suggest that both AGR2 and MIC-1 play a role in Docetaxel resistance in HRPC. Docetaxel anterior gradient 2, protein disulphide isomerase family member Homo sapiens