Title : Potent subunit-specific effects on cell growth and drug sensitivity from optimised siRNA-mediated silencing of ribonucleotide reductase.

Pub. Date : 2009 Mar 9

PMID : 19771229






1 Functional Relationships(s)
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1 Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analogs and more recently it has been shown that RRM2 knockdown itself has a growth inhibitory effect. Nucleosides ribonucleotide reductase catalytic subunit M1 Homo sapiens