Title : Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.

Pub. Date : 2009 Nov 13

PMID : 19762915






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In normal human chondrocytes, IGF-I initiated a strong and sustained phosphorylation of IRS-1 (Tyr-612) and Akt (Ser-473) and transient ERK phosphorylation. Tyrosine insulin like growth factor 1 Homo sapiens
2 In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation. Tyrosine insulin like growth factor 1 Homo sapiens