Title : Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis.

Pub. Date : 2010 Feb 1

PMID : 19760629






6 Functional Relationships(s)
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1 RESULTS: The IGF-1 level was correlated with BMD before ADT (rs = 0.325, P = 0.007), but such a relationship disappeared after ADT (P = 0.565). adt insulin like growth factor 1 Homo sapiens
2 Following ADT, the serum IGF-1 level increased compared with that at the baseline (22 +/- 6 nmol/L vs. 19 +/- 5 nmol/L, respectively, P < 0.001). adt insulin like growth factor 1 Homo sapiens
3 The ratio of the IGF-1 level after ADT/before ADT was associated with the ratio of the value after ADT/before ADT of alkaline phosphatase (rs = 0.266, P = 0.025) and calcium (rs = 0.242, P = 0.042). adt insulin like growth factor 1 Homo sapiens
4 The ratio of the IGF-1 level after ADT/before ADT was associated with the ratio of the value after ADT/before ADT of alkaline phosphatase (rs = 0.266, P = 0.025) and calcium (rs = 0.242, P = 0.042). adt insulin like growth factor 1 Homo sapiens
5 CONCLUSION: Despite the unaffected GH and upregulated bone resorption, the serum IGF-1 level was elevated by ADT. adt insulin like growth factor 1 Homo sapiens
6 The IGF-1 level was correlated with BMD before ADT, but the relationship was disrupted after ADT. adt insulin like growth factor 1 Homo sapiens