Title : GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells.

Pub. Date : 2010 Jan

PMID : 19759399






2 Functional Relationships(s)
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1 Overexpression of GM3 synthase in A2780 cells consistently resulted in elevated ganglioside (GM3, GM2 and GD1a) levels. Gangliosides ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Homo sapiens
2 In addition, the motility of low GM3 synthase expressing cells was also reduced in the presence of a Src kinase inhibitor; on the other hand, higher levels of the inactive form of c-Src were detected in GM3 synthase overexpressing cells, associated with a ganglioside- and caveolin-rich detergent insoluble fraction. Gangliosides ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Homo sapiens