Pub. Date : 2009 Nov
PMID : 19747365
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia. | mocetinostat | histone deacetylase 9 | Homo sapiens |
| 2 | MGCD0103, an orally available class I histone deacetylase (HDAC) inhibitor, was examined for pre-clinical activity in chronic lymphocytic leukaemia (CLL). | mocetinostat | histone deacetylase 9 | Homo sapiens |
| 3 | MGCD0103, an orally available class I histone deacetylase (HDAC) inhibitor, was examined for pre-clinical activity in chronic lymphocytic leukaemia (CLL). | mocetinostat | histone deacetylase 9 | Homo sapiens |
| 4 | MGCD0103 demonstrated pre-clinical activity against CLL cells with a LC(50) (concentration lethal to 50%) of 0.23 micromol/l and increased acetylation of the HDAC class I specific target histone H3. | mocetinostat | histone deacetylase 9 | Homo sapiens |