Title : Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3.

Pub. Date : 2009 Oct 13

PMID : 19743837






1 Functional Relationships(s)
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1 To investigate the structural and functional roles of the conserved polar residues in the N- and C-terminal transmembrane helices of human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3) (N-terminus, S33, S39, T41, and Q44; C-terminus, T490, T495, and C501), each was singly mutated to alanine. Alanine ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens