Pub. Date : 2009 Nov
PMID : 19741198
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 2 | Recent studies suggest that the rapid and nongenomic effects of estradiol may be mediated through the G protein-coupled receptor dubbed GPR30 receptor. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 3 | The present study examines the role of GPR30 versus a classical estrogen receptor (ERalpha) in mediating the growth regulatory effects of estradiol. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 4 | Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 5 | Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 6 | Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA). | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 7 | Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA). | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |