Title : Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition.

Pub. Date : 2009 Sep 15

PMID : 19738073






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 TGF-beta1-induced EMT and cell migration in A549 cells are associated with a decrease in IRS-1 tyrosine phosphorylation and protein levels. Tyrosine transforming growth factor beta 1 Homo sapiens
2 Inhibition of protein tyrosine phosphatase with sodium vanadate, which greatly increased the levels of tyrosine-phosphorylated IRS-1, suppressed TGF-beta1-induced actin remodeling and cell morphologic changes. Tyrosine transforming growth factor beta 1 Homo sapiens