Pub. Date : 2010 Mar
PMID : 19732952
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | P53 inhibition in B5/Bu250(6) cells using pifithrin-alpha alleviated these effects, suggesting a role for p53 therein; this observation was supported by the relative resistance of p53-null K562 cells to [DAC+Bu] combinations and by the effects of an anti-p53 shRNA on the OCI-AML3 cell line. | Busulfan | tumor protein p53 | Homo sapiens |
2 | We conclude that the synergistic effects of [DAC+Bu] are p53-dependent and involve cell cycle arrest, apoptosis induction and down-regulation of pro-survival genes. | Busulfan | tumor protein p53 | Homo sapiens |