Title : Involvement of both extrinsic and intrinsic apoptotic pathways in apoptosis induced by genistein in human cervical cancer cells.

Pub. Date : 2009 Aug

PMID : 19723056

3 Functional Relationships(s)
Compound Name
Protein Name
1 To determine the apoptotic pathway induced by genistein in the cervical cancer cells, we assessed activation of caspase-3, -8, and -9 by immunoblotting. Genistein caspase 3 Homo sapiens
2 Procaspase-3, -8, and -9 were decreased and PARP cleavage increased in a time-dependent manner after the treatment of genistein in HeLa cells. Genistein caspase 3 Homo sapiens
3 Also, inhibition of caspase-3, -8, and -9 with pharmacological inhibitors reduced genistein-mediated apoptosis. Genistein caspase 3 Homo sapiens