Title : Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.

Pub. Date : 2009 Nov

PMID : 19702782






1 Functional Relationships(s)
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1 One of the crucial interactions may be between the C20 ketone group (D-ring substituent at C17) of the neurosteroid, and the N407 and Y410 residues in the M4 domain of the receptor. Ketones cytokine like 1 Homo sapiens