Title : Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway.

Pub. Date : 2009 Oct 12

PMID : 19699196






1 Functional Relationships(s)
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1 Treatment of TAC animals with 5-aminoimidazole 1 carboxamide ribonucleoside (AICAR, 0.5 mg/g body wt), a specific activator of AMPK, inhibited cardiac hypertrophy in TAC and reversed PPARalpha, CPT-I and MCAD expression and fatty acid oxidation. 4-aminoimidazole acyl-CoA dehydrogenase medium chain Rattus norvegicus