Pub. Date : 2009 Oct
PMID : 19691357
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that catalyzes methylation of inorganic arsenic. | Arsenic | arsenite methyltransferase | Mus musculus |
2 | At 2 and 24 h after dosing, livers of As3mt knockouts contained a greater proportion of inorganic and monomethylated arsenic than did livers of C57BL/6 mice. | Arsenic | arsenite methyltransferase | Mus musculus |
3 | A similar predominance of inorganic and monomethylated arsenic was found in the urine of As3mt knockouts. | Arsenic | arsenite methyltransferase | Mus musculus |
4 | At 24 h after dosing, As3mt knockouts retained significantly higher percentages of arsenic dose in liver, kidneys, urinary bladder, lungs, heart, and carcass than did C57BL/6 mice. | Arsenic | arsenite methyltransferase | Mus musculus |
5 | These data confirm a central role for As3mt in the metabolism of inorganic arsenic and indicate that phenotypes for arsenic retention and distribution are markedly affected by the null genotype for arsenic methylation, indicating a close linkage between the metabolism and retention of arsenicals. | Arsenic | arsenite methyltransferase | Mus musculus |