Title : Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate.

Pub. Date : 2009 Oct

PMID : 19691357






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that catalyzes methylation of inorganic arsenic. Arsenic arsenite methyltransferase Mus musculus
2 At 2 and 24 h after dosing, livers of As3mt knockouts contained a greater proportion of inorganic and monomethylated arsenic than did livers of C57BL/6 mice. Arsenic arsenite methyltransferase Mus musculus
3 A similar predominance of inorganic and monomethylated arsenic was found in the urine of As3mt knockouts. Arsenic arsenite methyltransferase Mus musculus
4 At 24 h after dosing, As3mt knockouts retained significantly higher percentages of arsenic dose in liver, kidneys, urinary bladder, lungs, heart, and carcass than did C57BL/6 mice. Arsenic arsenite methyltransferase Mus musculus
5 These data confirm a central role for As3mt in the metabolism of inorganic arsenic and indicate that phenotypes for arsenic retention and distribution are markedly affected by the null genotype for arsenic methylation, indicating a close linkage between the metabolism and retention of arsenicals. Arsenic arsenite methyltransferase Mus musculus