Pub. Date : 2010 Jan 1
PMID : 19687166
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Accordingly, we determined the contribution of NHE-1 to cardiac glycoside-induced hypertrophy. | Glycosides | solute carrier family 9 member A1 | Rattus norvegicus |
| 2 | Conversely, both glycosides increased NHE-1 expression in cardiomyocytes by approximately two-fold and significantly increased intracellular sodium concentrations by more than 60% (P < 0.05). | Glycosides | solute carrier family 9 member A1 | Rattus norvegicus |
| 3 | CONCLUSION: When taken together, these studies show that NHE-1 inhibition attenuates the hypertrophic effect of cardiac glycosides without affecting inotropic parameters and suggest a possible approach to limiting glycoside-induced hypertrophic responses while preserving therapeutic, i.e. inotropic, actions. | Glycosides | solute carrier family 9 member A1 | Rattus norvegicus |
| 4 | CONCLUSION: When taken together, these studies show that NHE-1 inhibition attenuates the hypertrophic effect of cardiac glycosides without affecting inotropic parameters and suggest a possible approach to limiting glycoside-induced hypertrophic responses while preserving therapeutic, i.e. inotropic, actions. | Glycosides | solute carrier family 9 member A1 | Rattus norvegicus |