Title : Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.

Pub. Date : 2010 Jan

PMID : 19680820






5 Functional Relationships(s)
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1 The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4. Oximes acetylcholinesterase Cavia porcellus
2 The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4. Oximes acetylcholinesterase Cavia porcellus
3 The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4. Oximes acetylcholinesterase Cavia porcellus
4 The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4. Oximes acetylcholinesterase Cavia porcellus
5 Thus, tertiary oximes reactivated AChE in the brain, improved survival, and terminated seizures following GB intoxication. Oximes acetylcholinesterase Cavia porcellus