Pub. Date : 2009 Aug 15
PMID : 19679550
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. | Glycosides | tumor protein p53 | Homo sapiens |
| 2 | We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. | Glycosides | tumor protein p53 | Homo sapiens |
| 3 | This is the first report that cardiac glycoside drugs, by initiating the Src/MAPK signaling pathways, reduce the p53 levels via inhibition of p53 protein synthesis. | Glycosides | tumor protein p53 | Homo sapiens |
| 4 | This is the first report that cardiac glycoside drugs, by initiating the Src/MAPK signaling pathways, reduce the p53 levels via inhibition of p53 protein synthesis. | Glycosides | tumor protein p53 | Homo sapiens |