Pub. Date : 2009 Aug 11
PMID : 19666581
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both fibroblasts isolated from type 2 diabetic patients, and normal fibroblasts exposed chronically to high glucose, were defective in their capacity to up-regulate VEGF in response to hypoxia. | Glucose | vascular endothelial growth factor A | Homo sapiens |
| 2 | This resulted from a high glucose-induced decrease in transactivation by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), which mediates hypoxia-stimulated VEGF expression. | Glucose | vascular endothelial growth factor A | Homo sapiens |