Pub. Date : 2009 Sep
PMID : 19662644
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 2 | In the previous studies, (-)-epigallocatechin-3-gallate (EGCG) has been shown to have anticarcinogenic effects via modulation in protein expression of p53. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 3 | In the previous studies, (-)-epigallocatechin-3-gallate (EGCG) has been shown to have anticarcinogenic effects via modulation in protein expression of p53. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 4 | Using p53 positive Hep G2 and p53 negative Hep 3B cells, we found that treatment of EGCG resulted in dose-dependent inhibition of cellular proliferation, which suggests that the interaction of EGCG with p53 may not fully explain its inhibitory effect on proliferation. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 5 | Using p53 positive Hep G2 and p53 negative Hep 3B cells, we found that treatment of EGCG resulted in dose-dependent inhibition of cellular proliferation, which suggests that the interaction of EGCG with p53 may not fully explain its inhibitory effect on proliferation. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 6 | Using p53 positive Hep G2 and p53 negative Hep 3B cells, we found that treatment of EGCG resulted in dose-dependent inhibition of cellular proliferation, which suggests that the interaction of EGCG with p53 may not fully explain its inhibitory effect on proliferation. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 7 | Here, we showed that EGCG activated AMPK in both p53 positive and negative human hepatoma cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 8 | In p53 positive Hep G2 cells, EGCG blocked the progression of cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 9 | In p53 positive Hep G2 cells, EGCG blocked the progression of cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 10 | However, EGCG inducted apoptosis in p53 negative Hep 3B cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |