Title : Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor.

Pub. Date : 2009 Oct

PMID : 19659609






5 Functional Relationships(s)
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1 We have so far reported that an immunosuppressant cyclosporin A (CsA), a well-known cyclophilin (CyP) inhibitor (CPI), strongly suppressed hepatitis C virus (HCV) replication in cell culture, and that CyPB was a cellular cofactor for viral replication. Cyclosporine peptidylprolyl isomerase G Homo sapiens
2 We have so far reported that an immunosuppressant cyclosporin A (CsA), a well-known cyclophilin (CyP) inhibitor (CPI), strongly suppressed hepatitis C virus (HCV) replication in cell culture, and that CyPB was a cellular cofactor for viral replication. Cyclosporine peptidylprolyl isomerase G Homo sapiens
3 We have so far reported that an immunosuppressant cyclosporin A (CsA), a well-known cyclophilin (CyP) inhibitor (CPI), strongly suppressed hepatitis C virus (HCV) replication in cell culture, and that CyPB was a cellular cofactor for viral replication. Cyclosporine peptidylprolyl isomerase G Homo sapiens
4 We have so far reported that an immunosuppressant cyclosporin A (CsA), a well-known cyclophilin (CyP) inhibitor (CPI), strongly suppressed hepatitis C virus (HCV) replication in cell culture, and that CyPB was a cellular cofactor for viral replication. Cyclosporine peptidylprolyl isomerase G Homo sapiens
5 Knockdown of individual CyP subtypes revealed CyP40, in addition to CyPA and CyPB, contributed to viral replication, and CsA-resistant replicons acquired independence from CyPA for efficient replication. Cyclosporine peptidylprolyl isomerase G Homo sapiens