Title : Suppression of Th1- and Th2-type immune responses in infant mouse spleen after prenatal and postnatal exposure to low-level toluene and peptidoglycan.

Pub. Date : 2009 Aug

PMID : 19645570






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Exposure of mice to 5 or 50 ppm toluene resulted in increased immunoglobulin (Ig) G1 and decreased IgG2a and IgE antibodies in the plasma; significantly decreased T-bet, GATA-3, and Foxp3 mRNA in the spleen; and a tendency toward decreased interferon (IFN)-gamma mRNA in spleen. Toluene immunoglobulin heavy variable V1-9 Mus musculus
2 Exposure of mice to low-level toluene together with PGN stimulation resulted in decreased IgG1 as well as IgG2a antibodies in the plasma and Foxp3 mRNA in spleen as compared with control or PGN-treated mice. Toluene immunoglobulin heavy variable V1-9 Mus musculus