Title : mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-ABL protein.

Pub. Date : 2010 May

PMID : 19643477






1 Functional Relationships(s)
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Protein Name
Organism
1 Accordingly, its inhibition by imatinib mesylate (IM) lets p145 c-ABL translocate into the nuclear compartment, which drives cell growth arrest and apoptotic death. Imatinib Mesylate POM121 transmembrane nucleoporin Homo sapiens