Title : Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation.

Pub. Date : 2009 Nov

PMID : 19643121






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 UDP-glucuronosyltransferase (UGT) 2B17 is the most important catalyst of testosterone glucuronidation. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens
2 Human liver microsomes lacking functional UGT2B17 exhibited significantly higher sensitivity to ibuprofen, suggesting that UGT2B15 plays a major role in the residual testosterone glucuronidation activity in UGT2B17-deficient individuals. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens
3 Human liver microsomes lacking functional UGT2B17 exhibited significantly higher sensitivity to ibuprofen, suggesting that UGT2B15 plays a major role in the residual testosterone glucuronidation activity in UGT2B17-deficient individuals. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens