Title : Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.

Pub. Date : 2010 Jun

PMID : 19635928






1 Functional Relationships(s)
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1 Inhalation of the Asm inhibitors amitriptyline, trimipramine, desipramine, chlorprothixene, fluoxetine, amlodipine, or sertraline restored normal ceramide concentrations in murine bronchial epithelial cells, reduced inflammation in the lung of CF mice and prevented infection with Pseudomonas aeruginosa. Desipramine sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus