Title : Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.

Pub. Date : 2009 Oct 15

PMID : 19628476






3 Functional Relationships(s)
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1 A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity. Nicotine cholinergic receptor nicotinic beta 4 subunit Homo sapiens
2 Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers. Nicotine cholinergic receptor nicotinic beta 4 subunit Homo sapiens
3 Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers. Nicotine cholinergic receptor nicotinic beta 4 subunit Homo sapiens