Title : Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis.

Pub. Date : 2009 Oct 15

PMID : 19628475






1 Functional Relationships(s)
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1 Since neuronal acetylcholine receptors (nAChRs) are part of the glutamatergic pathway, we searched for sequence variants in CHRNA3, CHRNA4 and CHRNB4 genes, encoding neuronal nicotinic AChR subunits, in 245 SALS patients and in 450 controls. Acetylcholine cholinergic receptor nicotinic beta 4 subunit Homo sapiens